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E4CPG

CAT: 0804-HY-100372-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100372-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E4CPG ((RS) -ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation[1][2].
CAS Number
170846-89-6
Product Name Alternative
(RS) -ECPG
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/E4CPG.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic; adjust pH to 12 with NaOH) |H2O : < 0.1 mg/mL
Smiles
NC(C(O)=O)(CC)C1=CC=C(C(O)=O)C=C1
Molecular Formula
C11H13NO4
Molecular Weight
223.23
References & Citations
[1]N Sekiyama, et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptorsubtypes. Br J Pharmacol, 1996 Apr, 117 (7) :1493-503.|[2]J S Bedingfield, et al. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs) . Br J Pharmacol. 1995 Dec;116 (8) :3323-9.|[3]Christian Patenaude, et al. GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission. J Physiol. 2003 Nov 15;553 (Pt 1) :155-67.|[4]Alessandra Beirith, et al. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain Res. 2002 Jan 11;924 (2) :219-28.|[5]Jing Han, et al. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. 2012 Mar 2;148 (5) :1039-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR

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M17366-01E4CPG
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A20804-2E4CPG 2mg
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A20804-50E4CPG 50mg
A20804-10E4CPG 10mg

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