5-Iminodaunorubicin (hydrochloride)

5-Iminodaunorubicin (hydrochloride)

• CAS Number: 67324-99-6
• UNSPSC Description: 5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells[2].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/5-iminodaunorubicin-hydrochloride.html
• Smiles: COC(C=CC=C1C(C2=C(O)C(C[C@@](C(C)=O)(C[C@@H]3O[C@@H]4O[C@H]([C@H]([C@H](C4)N)O)C)O)=C3C(O)=C52)=O)=C1C5=N.[H]Cl
• Molecular Weight: 563.00
• References & Citations: [1]R A Jensen, et al. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Cancer Res. 1984 Sep;44(9):4030-9.|[2]L A Zwelling, et al. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide. Cancer Res. 1982 Jul;42(7):2687-91.
• Shipping Conditions: Room Temperature