RANK L/TNFSF11, Mouse (HEK293, N-His)
CAT:
804-HY-P7425B-04
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
RANK L/TNFSF11, Mouse (HEK293, N-His)
- UNSPSC Description: RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-κB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANK L/TNFSF11 Protein, Mouse (HEK293, C-His) is a recombinant mouse RANKL (R72-D316) with N-terminal 6*His tag, which is produced in HEK293[1][2].
- Type: Recombinant Proteins
- Assay Protocol: https://www.medchemexpress.com/cytokines/rank-l-tnfsf11-protein-mouse-hek293-c-his.html
- Purity: 97.25
- Smiles: RAQMDPNRIS EDSTHCFYRI LRLHENADLQ DSTLESEDTL PDSCRRMKQA FQGAVQKELQ HIVGPQRFSG APAMMEGSWL DVAQRGKPEA QPFAHLTINA ASIPSGSHKV TLSSWYHDRG WAKISNMTLS NGKLRVNQDG FYYLYANICF RHHETSGSVP TDYLQLMVYV VKTSIKIPSS HNLMKGGSTK NWSGNSEFHF YSINVGGFFK LRAGEEISIQ VSNPSLLDPD QDATYFGAFK VQDID
- Molecular Weight: Approximately 32-35 kDa due to the glycosylation.
- References & Citations: [1]Ono T, et al. RANKL biology: bone metabolism, the immune system, and beyond. Inflamm Regen. 2020 Feb 7;40:2.|[2]Li B, et al. Roles of the RANKL-RANK Axis in Immunity-Implications for Pathogenesis and Treatment of Bone Metastasis. Front Immunol. 2022 Mar 21;13:824117.|[3]Tobeiha M, et al. RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling. Biomed Res Int. 2020 Feb 19;2020:6910312.|[4]Shimamura M, et al. OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8191-6.|[5]He X, et al. Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production. Biochem Biophys Res Commun. 2010 Oct 22;401(3):356-62.
- Shipping Conditions: Blue Ice
- Storage Conditions: Stored at -20°C for 2 years