M344

• Description :

  M344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.

• Product Name Alternative :

  D 237; MS 344

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/M344.html

• Purity :

  99.76

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1

• Molecular Formula :

  C16H25N3O3

• Molecular Weight :

  307.39

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Jung M1, et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem. 1999 Nov 4;42 (22) :4669-79.|[2]Weberpals JI, et al. The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells. Cancer Cell Int. 2011 Aug 19;11 (1) :29.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC

• CAS Number :

  [251456-60-7]