N-Acetyl-Ser-Asp-Lys-Pro (acetate)

N-Acetyl-Ser-Asp-Lys-Pro (acetate)

• UNSPSC Description: N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties[1][2].
• Target Antigen: Angiotensin-converting Enzyme (ACE)
• Type: Peptides
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/n-acetyl-ser-asp-lys-pro-acetate.html
• Purity: 98.93
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C([C@@H](CC(O)=O)NC([C@H](CO)NC(C)=O)=O)N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(O)=O)=O.CC(O)=O
• Molecular Weight: 547.56
• References & Citations: [1]Peng H, et al. Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension. Hypertension. 2003;42(6):1164-1170.|[2]Sharma U, et al. Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol. 2008;294(3):H1226-H1232.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported