Bobcat339

CAT: 0804-HY-111558-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-111558-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].

CAS Number

2280037-51-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA Methyltransferase; TET Protein

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bobcat339.html

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O

Molecular Formula

C16H12ClN3O

Molecular Weight

297.74

Precautions

H302, H315, H319, H335

References & Citations

[1]Chua GNL, et, al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31; 10 (2) : 180-185.|[2]Weirath NA, et al. Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper (II) . ACS Med Chem Lett. 2022 Apr 21;13 (5) :792-798.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TET1; TET2

Citation 01

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