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Albendazole

CAT: 0804-HY-B0223-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0223-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].
CAS Number
54965-21-8
Product Name Alternative
SKF-62979
UNSPSC
12352005
Hazard Statement
H361, H373, H410
Target
Antibiotic; Apoptosis; Autophagy; Bacterial; HIF/HIF Prolyl-Hydroxylase; Microtubule/Tubulin; Parasite; Reactive Oxygen Species (ROS) ; VEGFR
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Albendazole.html
Concentration
10mM
Purity
99.05
Solubility
DMSO : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(OC)NC1=NC2=CC=C(SCCC)C=C2N1
Molecular Formula
C12H15N3O2S
Molecular Weight
265.33
Precautions
H361, H373, H410
References & Citations
[1]Vural G, et al. Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice. Parasitology. 2020 Nov;147 (13) :1425-1432.|[2]Li L, et al. Determination of albendazole and metabolites in silkworm Bombyx mori hemolymph by ultrafast liquid chromatography tandem triple quadrupole mass spectrometry. PLoS One. 2014 Sep 25;9 (9) :e105637.|[3]Pourgholami MH, et al. In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by albendazole. Cancer Lett. 2001 Apr 10;165 (1) :43-9.|[4]Jung YY, et al. Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells. Biochimie. 2022 Jul;198:155-166.|[5]Zhou F, et al. Albendazole inhibits HIF-1α-dependent glycolysis and VEGF expression in non-small cell lung cancer cells. Mol Cell Biochem. 2017 Apr;428 (1-2) :171-178.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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