Propiomazine

• Description:

  Propiomazine is an orally active antihistamine agent with sedative effects. Propiomazine can be used in the research of insomnia[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/propiomazine.html

• Purity:

  98.91

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  CCC(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)=O

• Molecular Formula:

  C20H24N2OS

• Molecular Weight:

  340.48

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57 (4) :239-42. |[2]Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037. |[3]C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224. |[4]F T Serratoni, et al. Promethazine protection in carbon tetrachloride liver injury. An electron microscopic study. Arch Pathol. 1969 Jan;87 (1) :46-51. |[5]Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178 (4) :606-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [362-29-8]