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KPZ560

CAT: 0804-HY-156422-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156422-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KPZ560 is a potent inhibitor of HDAC1 and HDAC2, with IC50s of 12 nM and 68 nM, respectively. KPZ560 can increase in the spine density of granule neuron dendrites of mice and inhibitor cell growth of breast cancer cell line MCF[1].
CAS Number
2397562-43-3
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kpz560.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C(C=C(C=C1)C2=CC=CS2)NC(C3=CC=C(C=C3)C4=CN(N=N4)CS(C5=CC=CC=C5)(=O)=O)=O
Molecular Formula
C26H21N5O3S2
Molecular Weight
515.61
References & Citations
[1]Yukihiro Itoh, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. J Med Chem. 2023 Oct 17. doi: 10.1021/acs.jmedchem.3c01095. Online ahead of print.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2

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