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L-threo-Droxidopa

CAT: 0572-TRC-D689960-250MGSize: 250 mgDry Ice: NoHazardous: No
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CAT#:0572-TRC-D689960-250MGSize:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
23651-95-8
Synonyms
L-Tyrosine, β,3-dihydroxy-, (βR)-; L-Tyrosine, β,3-dihydroxy-, threo-; Serine, 3-(3,4-dihydroxyphenyl)-, L-threo- (8CI); (βR)-β,3-Dihydroxy-L-tyrosine; (-)-threo-3,4-Dihydroxyphenylserine; (2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid; DOPS; Droxidopa; L-DOPS; L-Threodops; L-threo-3,4-Dihydroxyphenylserine; L-threo-3-(3,4-Dihydroxyphenyl)serine; L-threo-DOPS; L-threo-β-(3,4-Dihydroxyphenyl)serine; Northera; SM 5688; threo-3-(3,4-Dihydroxyphenyl)-L-serine; threo-Dopaserine
Hazard Statement
Causes skin irritation
Purity
>95% (HPLC)
Smiles
N[C@@H]([C@H](O)c1ccc(O)c(O)c1)C(=O)O
Molecular Formula
C9 H11 N O5
Molecular Weight
213.19
InChI
InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
Additionnal Information
IUPAC name: (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
Shipping Conditions
Room Temperature
Storage Conditions
+4°C

Chemical Information

Droxidopa

Droxidopa is a serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension. It has a role as an antihypertensive agent, a prodrug and a vasoconstrictor agent. It is a L-tyrosine derivative and a member of catechols.

CAS Number23651-95-8
PubChem CID92974
IUPAC Name(2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
Molecular FormulaC9H11NO5
Molecular Weight213.19
XLogP-3.2
Topological Polar Surface Area124
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count15
Formal Charge0
Complexity235
SMILES
C1=CC(=C(C=C1[C@H]([C@@H](C(=O)O)N)O)O)O
InChI
InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
InChIKey
QXWYKJLNLSIPIN-JGVFFNPUSA-N
Chemical Structure
2D Structure
2D structure of Droxidopa
CAS: 23651-95-8
CID: 92974
Formula: C9H11NO5
MW: 213.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight213.19
XLogP3-3.2
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass213.06372245
Monoisotopic Mass213.06372245
Topological Polar Surface Area124 Ų
Heavy Atom Count15
Formal Charge0
Complexity235
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
290156-01L-threo-droxidopa
HY-W778064L-threo-Droxidopa-13C2,15N
AR-D02240-01L-threo-Droxidopa-13C2-15N
290155-01DL-threo-droxidopa
AR-D07818-01L-threo-Droxidopa-13C2-15N HCl
011004D, L-threo-Droxidopa-13C2,15N Hydrochloride
454099-01M, p-O-Dimethyl-L-threo-droxidopa
447558-01DL-threo-Droxidopa-d3
MBS6023860-01D,L-threo-Droxidopa-13C2,15N Hydrochloride
454100M, p-O-Dimethyl-L-threo-droxidopa-d6

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