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OK2

CAT: 0804-HY-P5314-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P5314-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research[1].
UNSPSC
12352209
Target
EGFR; STAT
Type
Peptides
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ok2.html
Purity
99.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H](C)[C@@H](C(N1)=O)NC([C@H](CC2=CNC3=CC=CC=C32)NC([C@@H]4CCCN4C([C@H](CCCNC(N)=N)NC([C@H](CC5=CNC=N5)NC([C@H](CCCCN)NC([C@@H]1[C@H](O)C)=O)=O)=O)=O)=O)=O
Molecular Formula
C42H62N14O9
Molecular Weight
907.03
References & Citations
[1]Dong J, et.al. Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment. J Med Chem. 2023 Jun 22;66 (12) :8251-8266.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
STAT3

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