IL-2R alpha/CD25, Cynomolgus (HEK293)

• UNSPSC Description:

  IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions[1][2]. IL-2R alpha/CD25 Protein, Cynomolgus (HEK293) is a recombinant cynomolgus IL-2R alpha protein and is expressed in HEK293 cells. It consists of 213 amino acids (M1-R213).

• Type:

  Recombinant Proteins

• Assay Protocol:

  https://www.medchemexpress.com/cytokines/il-2r-alpha-cd25-protein-cynomolgus-hek293.html

• Molecular Weight:

  38-42 kDa

• References & Citations:

  [1]H.Asao. Interleukin-2. Reference Module in Biomedical Sciences. 2014. ISBN 9780128012383.|[2]Kim HP, et al. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity. 2001 Jul;15(1):159-72.|[3]Bell CJ, et al. Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells. J Autoimmun. 2015 Jan;56:66-80.|[4]Chistiakov DA, et al. The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett. 2008 Jun 15;118(1):1-5.

• Shipping Conditions:

  Room temperature