Human CDK2 Protein

Human CDK2 Protein_x000D_ Catalog number: B2011906_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 0.5 mg/mL_x000D_ Supplied as: Solution_x000D_ Applications: molecular tool for various biochemical applications_x000D_ Storage: -20 °C_x000D_ Keywords: CDK-2 protein, CDK 2, CDK2, p33 protein, CDK-2, CDK 2 protein, CDK2 protein, Cyclin-depentent kinase 2 protein_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Tadesse S, Anshabo AT, Portman N, Lim E, Tilley W, Caldon CE, Wang S. Targeting CDK2 in cancer: challenges and opportunities for therapy Drug Discov Today. 2020 Feb;25(2):406-413._x000D_ 2: Tadesse S, Caldon EC, Tilley W, Wang S. Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update J Med Chem. 2019 May 9;62(9):4233-4251._x000D_ 3: Bitencourt-Ferreira G, de Azevedo WF Jr. Docking with SwissDock Methods Mol Biol. 2019;2053:189-202._x000D_ 4: Wang L, Shao X, Zhong T, Wu Y, Xu A, Sun X, Gao H, Liu Y, Lan T, Tong Y, Tao X, Du W, Wang W, Chen Y, Li T, Meng X, Deng H, Yang B, He Q, Ying M, Rao Y. Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy Nat Chem Biol. 2021 May;17(5):567-575._x000D_ 5: Hati S, Zallocchi M, Hazlitt R, Li Y, Vijayakumar S, Min J, Rankovic Z, Lovas S, Zuo J. AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss Eur J Med Chem. 2021 Dec 15;226:113849._x000D_ 6: Ying M, Shao X, Jing H, Liu Y, Qi X, Cao J, Chen Y, Xiang S, Song H, Hu R, Wei G, Yang B, He Q. Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2 Blood. 2018 Jun 14;131(24):2698-2711._x000D_ 7: de Azevedo WF. Protein-Ligand Interactions: High-Resolution Structures of CDK2 Curr Drug Targets. 2022;23(5):438-440._x000D_ 8: Lee JH, Shamanna RA, Kulikowicz T, Borhan Fakouri N, Kim EW, Christiansen LS, Croteau DL, Bohr VA. CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice Aging Cell. 2021 Nov;20(11):e13484._x000D_ 9: Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit Cell. 2013 Oct 10;155(2):369-83._x000D_ 10: Nahálková J, Tomkinson B. TPPII, MYBBP1A and CDK2 form a protein-protein interaction network Arch Biochem Biophys. 2014 Dec 15;564:128-35. _x000D_ _x000D_ Products Related to Human CDK2 Protein can be found at Proteins

Catalog Number: B2011906 (50 µg)

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