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Piroxantrone

CAT: 0804-HY-13726Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13726Size:1 Each
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Description
Piroxantrone (Oxantrazole) is a potent DNA topoisomerase II-targeting anthrapyrazole antitumor agent. Piroxantrone displays cardiotoxicity[1][2].
CAS Number
91441-23-5
Product Name Alternative
Oxantrazole; NCS 349174
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/piroxantrone.html
Smiles
O=C1C2=C3C(N(N=C3C4=C(C=CC(O)=C14)O)CCNCCO)=CC=C2NCCCN
Molecular Formula
C21H25N5O4
Molecular Weight
411.45
References & Citations
[1]Hasinoff BB, et al. The displacement of iron (III) from its complexes with the anticancer drugs piroxantrone and losoxantrone by the hydrolyzed form of the cardioprotective agent dexrazoxane. J Inorg Biochem. 1999 Nov-Dec;77 (3-4) :257-9.|[2]Frank SK, et al. Preclinical pharmacology of the anthrapyrazole analog oxantrazole (NSC-349174, piroxantrone) . Cancer Chemother Pharmacol. 1989;23 (4) :213-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
AR-P31924-01Piroxantrone

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