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Pridopidine

CAT: 0804-HY-10684-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10684-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100x higher than its affinity toward D2R.
CAS Number
346688-38-8
Product Name Alternative
ACR16; ASP2314; FR310826
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pridopidine.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(C2CCN(CCC)CC2)=CC=C1)(C)=O
Molecular Formula
C15H23NO2S
Molecular Weight
281.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Geva M, et al. Pridopidine activates neuroprotective pathways impaired in Huntington Disease. Hum Mol Genet. 2016 Sep 15;25 (18) :3975-3987.|[2]Squitieri F, et al. Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse J Cell Mol Med. 2015 Nov;19 (11) :2540-8. model.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
D2 Receptor

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