Cabazitaxel

• Description:

  Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

• Product Name Alternative:

  XRP6258; RPR-116258A; taxoid XRP6258

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H341, H361, H373

• Target:

  Autophagy; Microtubule/Tubulin

• Type:

  Natural Products

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Cabazitaxel.html

• Purity:

  99.98

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  CC1=C([C@@H](OC)C([C@@]2(C)[C@@]3([H])[C@](OC(C)=O)(CO4)[C@H]4C[C@@H]2OC)=O)C(C)(C)[C@@]([C@H]3OC(C5=CC=CC=C5)=O)(O)C[C@@H]1OC([C@H](O)[C@H](C6=CC=CC=C6)NC(OC(C)(C)C)=O)=O

• Molecular Formula:

  C45H57NO14

• Molecular Weight:

  835.93

• Precautions:

  H302, H315, H341, H361, H373

• References & Citations:

  [1]Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29.|[2]Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond) . 2017 Sep;12 (17) :2083-2095.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  [183133-96-2]