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H-Val-Pro-Pro-OH (TFA)

CAT: 0804-HY-114161A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114161A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.
CAS Number
2828433-08-3
Product Name Alternative
GCA-1
UNSPSC
12352209
Target
Angiotensin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/H-Val-Pro-Pro-OH_TFA.html
Purity
98.0
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
N[C@@H](C(C)C)C(N1CCC[C@H]1C(N2CCC[C@H]2C(O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C17H26F3N3O6
Molecular Weight
425.40
References & Citations
[1]Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78 (4) :777-83.|[2]Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66 (39) :10179-10187.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Val-Pro-Pro-OH TFA
CAS Number2828433-08-3
PubChem CID137319716
IUPAC Name(2S)-1-[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid;2,2,2-trifluoroacetic acid
Molecular FormulaC17H26F3N3O6
Molecular Weight425.4
Topological Polar Surface Area141
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity549
SMILES
CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)O)N.C(=O)(C(F)(F)F)O
InChI
InChI=1S/C15H25N3O4.C2HF3O2/c1-9(2)12(16)14(20)17-7-3-5-10(17)13(19)18-8-4-6-11(18)15(21)22;3-2(4,5)1(6)7/h9-12H,3-8,16H2,1-2H3,(H,21,22);(H,6,7)/t10-,11-,12-;/m0./s1
InChIKey
DJQRQUZDHQFFTH-LFELFHSZSA-N
Chemical Structure
2D Structure
2D structure of H-Val-Pro-Pro-OH TFA
CAS: 2828433-08-3
CID: 137319716
Formula: C17H26F3N3O6
MW: 425.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight425.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass425.17737004
Monoisotopic Mass425.17737004
Topological Polar Surface Area141 Ų
Heavy Atom Count29
Formal Charge0
Complexity549
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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GTR19029678-01H-Val-Pro-Pro-OH TFA (58872-39-2 free base)
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FG108892-01H-Gln-Gly-Pro-OH·TFA
GTR19234356-01Asn-Pro-Val-PABC-MMAE TFA
T78409L-01Boc-Val-Pro-Arg-MCA TFA
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