Phosphorylcholine

• Description:

  Phosphatidylcholine is the main phospholipid component in eukaryotic biofilms. Phosphatidylcholine exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Phosphorylcholine exhibits a surprising range of immunomodulatory properties[1].

• Product Name Alternative:

  Phosphocholine

• UNSPSC:

  12352211

• Target:

  Adrenergic Receptor; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Field of Research:

  Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/phosphorylcholine-1.html

• Purity:

  98.0

• Solubility:

  DMSO : < 1 mg/mL|Ethanol : 4 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=P(OCC[N+](C)(C)C)([O-])O

• Molecular Formula:

  C5H14NO4P

• Molecular Weight:

  183.14

• References & Citations:

  [1]Harnett W, et al. Phosphorylcholine: friend or foe of the immune system? Immunol Today. 1999 Mar;20 (3) :125-9.|[2]Tu S, et al., Enhancement of cellular uptake and antitumor efficiencies of micelles with phosphorylcholine. Macromol Biosci. 2011 Oct 10;11 (10) :1416-25.|[3]Cansev M, et al., Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system. Eur J Pharmacol. 2008 Jul 28;589 (1-3) :315-22.|[4]Caligiuri G, et al., Phosphorylcholine-targeting immunization reduces atherosclerosis. J Am Coll Cardiol. 2007 Aug 7;50 (6) :540-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite; Microbial Metabolite

• Citation 01:

  Adv Sci (Weinh) . 2024 Dec 4:e2411276.|Anal Chem. 2025 May 13;97 (18) :9827-9835.|JCI Insight. 2021 Oct 22;6 (20) :e151911.|Nat Commun. 2023 Mar 24;14 (1) :1631.|Nature. 2025 Jul;643 (8070) :192-200.|NPJ Biofilms Microbiomes. 2023 Sep 4;9 (1) :62.|Patent. US20250160318A1.|Virulence. 2025 Dec;16 (1) :2490208.|J Physiol Biochem. 2022 May;78 (2) :355-363.

• CAS Number:

  [3616-04-4]