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NVP018

CAT: 0804-HY-125640Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-125640Size:Inquire
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CAS Number
1401924-49-9
UNSPSC Description
NVP018 (BC556) is an orally active inhibitor for cyclophilin A with IC50 of 0.3 and 0.1 nM for cyclophilin A and NS5A- cyclophilin A complex. NVP018 inhibits Bilirubin (HY-N0323) transporter OATP1B1 and OATP1B3 with IC50 of 4.31 and 1.75 μM. NVP018 inhibits the replication of HBV (in HepG2), HCV (in Huh-7) and HIV-1 (in HeLa), with IC50 in nanomolar levels. NVP018 exhibits anti-fibrotic effect by inhibiting the mRNA expression of COL1A1 and LOX[1][2].
Target Antigen
Cyclophilin; HBV; HCV; HIV
Type
Reference compound
Related Pathways
Anti-infection;Immunology/Inflammation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nvp018.html
Smiles
O=C(N1N[C@](CCC1)([H])C(O[C@@H](C/C=C/C=C/[C@@H]([C@@H]([C@H]([C@H](C(N[C@H](C(N2)=O)C(C)C)=O)CCC(C)=O)O)C)O)/C(C)=C/C=C/C(N3CCCCO3)=O)=O)[C@@H]2CC4=CC(F)=CC(O)=C4
Molecular Weight
868.00
References & Citations
[1]Hansson MJ, et al., Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection. Chem Biol. 2015 Feb 19;22(2):285-92. |[2]Simón Serrano S, et al., Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis. Cells. 2019 Nov 8;8(11):1409.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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CatalogName
T70760-01NVP018

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