D-Glucan

• Description :

  D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α) . D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism) [1][2][3][4].

• CAS Number :

  [9012-72-0]

• UNSPSC :

  12352200

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Toll-like Receptor (TLR)

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/d-glucan.html

• Purity :

  96.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  [D-Glucan]

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Ljungman AG, et al. (1→3) -β-d-Glucan stimulates nitric oxide generation and cytokine mRNA expression in macrophages. Environ Toxicol Pharmacol. 1998 Jun 2;5 (4) :273-81.|[2]Toklu HZ, et al. Acetaminophen-induced toxicity is prevented by beta-D-glucan treatment in mice. Eur J Pharmacol. 2006 Aug 14;543 (1-3) :133-40.|[3]Tabeie F, et al. Radioprotective Effect of Beta D-Glucan and Vitamin E on Gamma Irradiated Mouse. J Clin Diagn Res. 2017 Feb;11 (2) :TC08-TC11.|[4]Liu M, et al. The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice. Int J Biol Macromol. 2016 Oct;91:1170-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported