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D-Glucan

CAT: 0804-HY-134816-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134816-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α) . D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism) [1][2][3][4].
CAS Number
[9012-72-0]
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Toll-like Receptor (TLR)
Type
Biochemical Assay Reagents
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/d-glucan.html
Purity
96.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[D-Glucan]
Precautions
H302, H315, H319, H335
References & Citations
[1]Ljungman AG, et al. (1→3) -β-d-Glucan stimulates nitric oxide generation and cytokine mRNA expression in macrophages. Environ Toxicol Pharmacol. 1998 Jun 2;5 (4) :273-81.|[2]Toklu HZ, et al. Acetaminophen-induced toxicity is prevented by beta-D-glucan treatment in mice. Eur J Pharmacol. 2006 Aug 14;543 (1-3) :133-40.|[3]Tabeie F, et al. Radioprotective Effect of Beta D-Glucan and Vitamin E on Gamma Irradiated Mouse. J Clin Diagn Res. 2017 Feb;11 (2) :TC08-TC11.|[4]Liu M, et al. The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice. Int J Biol Macromol. 2016 Oct;91:1170-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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