BIX02188

• Description:

  BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ERK; MEK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/BIX02188.html

• Concentration:

  10mM

• Purity:

  99.85

• Solubility:

  DMSO : ≥ 45 mg/mL

• Smiles:

  O=C (N) C1=CC (NC2=O) =C (/C2=C (C3=CC=CC=C3) /NC4=CC=CC (CN (C) C) =C4) C=C1

• Molecular Formula:

  C25H24N4O2

• Molecular Weight:

  412.49

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Li L, et al. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23;370 (1) :159-63.|[2]Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377 (1) :120-5.|[3]Badshah II, et al. Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. Front Pharmacol. 2014 Apr 21;5:71.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ERK5; MEK5

• CAS Number:

  334949-59-6