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Penfluridol (Standard)

CAT: 0804-HY-B1077R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1077R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Penfluridol (Standard) is the analytical standard of Penfluridol. This product is intended for research and analytical applications. Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca2+-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 µg/ml[1][2][3][4].
CAS Number
26864-56-2
Product Name Alternative
R-16341 (Standard)
UNSPSC
12352005
Target
Apoptosis; Autophagy; Calcium Channel; Dopamine Receptor; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/penfluridol-standard.html
Smiles
OC1(C2=CC=C(Cl)C(C(F)(F)F)=C2)CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC1
Molecular Formula
C28H27ClF5NO
Molecular Weight
523.97
References & Citations
[1]Eyal Zur, et al. Penfluridol, a Unique Psychiatric Medicine for the Treatment of Chronic Schizophrenia. Int J Pharm Compd. 2019 Mar-Apr;23 (2) :113-119.|[2]Yue-Hong Chen, et al. Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases. Arthritis Res Ther. 2022 Jan 19;24 (1) :27.|[3]Xianghai Zeng, et al. Drug repurposing: Antimicrobial and antibiofilm effects of penfluridol against Enterococcus faecalis. Microbiologyopen. 2021 Jan;10 (1) :e1148.|[4]Szu-Yuan Wu, et al. Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses. J Biomed Sci. 2019 Aug 31;26 (1) :63.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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