Recombinant Human Claudin-18.2 (CLDN18.2) -Detergent (Active)

Recombinant Human Claudin-18.2 (CLDN18.2) -Detergent (Active)

• CAS Number: 9000-83-3
• Gene Name: CLDN18.2
• UniProt: P56856-2
• Expression Region: 1-261aa
• Organism: Homo sapiens
• Target Sequence: MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
• Tag: C-terminal 10xHis-tagged
• Source: Mammalian cell
• Field of Research: Signal Transduction
• Assay Type: MP-Detergent Transmembrane Protein & Active Protein & In Stock Protein
• Relevance: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
• Purity: Greater than 80% as determined by SDS-PAGE.
• Activity: Yes
• Bioactivity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 at 5 μg/mL on an Nickel Coated plate can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005505MA1HU), the EC50 is 0.4640-0.6372 ng/mL.
• Length: Full Length of Isoform A2
• Form: Liquid
• Buffer: 50 mM HEPES，0.15 M NaCl， 0.05% DDM，0.01% CHS，pH7.5
• Molecular Weight: 29.1 kDa
• References & Citations: "Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development." Sahin U., Koslowski M., Dhaene K., Usener D., Brandenburg G., Seitz G., Huber C., Tuereci O. Clin. Cancer Res. 14:7624-7634 (2008)
• Storage Conditions: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.