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VLX600

CAT: 0804-HY-12406-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12406-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS) . VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity[1][2].
CAS Number
327031-55-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Autophagy; Mitochondrial Metabolism; Oxidative Phosphorylation
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vlx600.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=C(NC2=C3N=NC(N/N=C(C4=CC=CC=N4)\C)=N2)C3=CC=C1
Molecular Formula
C17H15N7
Molecular Weight
317.35
Precautions
H315, H319, H335
References & Citations
[1]Karlsson H, et al. A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation. Oncotarget. 2019 Sep 3;10 (51) :5372-5382.|[2]Zhang X, et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014;5:3295.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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