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MELK-IN-1

CAT: 0804-HY-101515-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101515-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.
CAS Number
2095596-44-2
UNSPSC
12352005
Target
MELK
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MELK-IN-1.html
Purity
98.03
Solubility
DMSO : 13.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC2=C(NC(/C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)=O)C=C1)OC
Molecular Formula
C31H33N5O4
Molecular Weight
539.62
References & Citations
[1]Edupuganti R, et al. Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem. 2017 May 1;25 (9) :2609-2616.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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