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Glufosfamide

CAT: 0804-HY-16232-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16232-01Size:5 mg
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Description
Glufosfamide is a glucose-conjugated alkylating cytotoxic agent and a derivative of Ifosfamide. Glufosfamide induces apoptosis frequency and increase the expression of caspase-9 and caspase-3 in cancer cells. Glufosfamide shows great anti-tumor activity in MiaPaCa-2-RFP mouse model. Glufosfamide can be used for the study of hepatocellular carcinoma, prostate cancer and pancreatic carcinoma[1][2][3].
CAS Number
132682-98-5
Product Name Alternative
D 19575; Glucosylifosfamide mustard
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bcl-2 Family; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GLUFOSFAMIDE.html
Purity
98.0
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](O)[C@H](OP(NCCCl)(NCCCl)=O)O[C@H](CO)[C@H]1O
Molecular Formula
C10H21Cl2N2O7P
Molecular Weight
383.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Ahmed DE, et al. An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart. J Egypt Natl Canc Inst. 2021 Aug 23;33 (1) :22. |[2]Ammons WS, et al. A novel alkylating agent, glufosfamide, enhances the activity of gemcitabine in vitro and in vivo. Neoplasia. 2007 Aug;9 (8) :625-33. |[3]Attia RT, et al. The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ. 2016 Jun 29;4:e2168.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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sc-506131Glufosfamide
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