Trazodone

• Description:

  Trazodone (AF-1161 free base) is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs) . Trazodone has anti-depressant and anti-insomnious activity. Trazodone exerts antagonistic properties against a1- and a2-adrenergic receptors and histamine H1 receptors, with minimal anticholinergic effects[1].

• Product Name Alternative:

  AF-1161 (free base)

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  5-HT Receptor; Adrenergic Receptor; Histamine Receptor; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/trazodone.html

• Concentration:

  10mM

• Purity:

  99.84

• Solubility:

  DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C4C=CC=CN41

• Molecular Formula:

  C19H22ClN5O

• Molecular Weight:

  371.86

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Fagiolini A, et, al. Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 2012 Dec;26 (12) :1033-49.|[2]Brogden, R. N., et al., (1981) . Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 21 (6), 401–429.|[3]Raffa, R. B., et al., (1992) . Etoperidone, trazodone and MCPP: in vitro and in vivo identification of serotonin 5-HT1A (antagonistic) activity. Psychopharmacology, 108 (3), 320–326.|[4]Ghanbari, R., et al., (2010) . Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain. The Journal of pharmacology and experimental therapeutics, 335 (1), 197–206.|[5]Jay AR, Krotscheck U, Parsley E, Benson L, Kravitz A, Mulligan A, Silva J, Mohammed H, Schwark WS. Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs. Am J Vet Res. 2013 Nov;74 (11) :1450-6.|[6]Daniele S, et al. Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK. Cell Signal. 2015 Aug;27 (8) :1609-29.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Anal Bioanal Chem. 2025 Jul;417 (16) :3703-3714.|Int Immunopharmacol. 2025 Jan 6:147:113969.|ACS Omega. 2025 Oct 17;10 (42) :50208-50217.|Clin Chem. 2019 Dec;65 (12) :1522-1531. |University of Cambridge. 2023 Feb.|University of South Carolina. 2025.

• CAS Number:

  [19794-93-5]