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OTUB2-IN-1

CAT: 0804-HY-160768-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160768-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OTUB2-IN-1, a specific inhibitor of OTUB2 (KD: ~12 μM), reduces PD-L1 protein expression in tumor cells and inhibits tumor growth by promoting robust intra-tumor infiltration of cytotoxic T lymphocytes (CTL) [1].
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/otub2-in-1.html
Purity
98.79
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(CCCCCN1C(S/C(C1=O)=C2C(C=CC=C3)=C3N(CC(O)=O)C\2=O)=S)=O
Molecular Formula
C19H18N2O6S2
Molecular Weight
434.49
References & Citations
[1]Ren W et al. Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. Nat Commun. 2024 Jan 2;15 (1) :9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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