Silybin

• Description :

  Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

• Product Name Alternative :

  Silibinin

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Apoptosis

• Type :

  Natural Products

• Related Pathways :

  Apoptosis

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/silybin.html

• Purity :

  99.91

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C1[C@H](O)[C@@H](C2=CC=C(OC(CO)C(C3=CC=C(O)C(OC)=C3)O4)C4=C2)OC5=CC(O)=CC(O)=C15

• Molecular Formula :

  C25H22O10

• Molecular Weight :

  482.44

• Precautions :

  H302

• References & Citations :

  [1]Silvia Zappavigna, et al. Silybin-Induced Apoptosis Occurs in Parallel to the Increase of Ceramides Synthesis and miRNAs Secretion in Human Hepatocarcinoma Cells. Int J Mol Sci. 2019 May 3;20 (9) :2190.|[2]Runbin Sun, et al. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomed Pharmacother. 2020 Mar;123:109721.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 4

• CAS Number :

  [802918-57-6]