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Crustecdysone

CAT: 0804-HY-N6979-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6979-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone.
CAS Number
5289-74-7
Product Name Alternative
20-Hydroxyecdysone
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Caspase; Endogenous Metabolite
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/crustecdysone.html
Concentration
10mM
Purity
99.23
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@@H]1[C@H](O)C[C@](C(C=C2[C@]3([H])CC[C@@]4(C)[C@@]2(O)CC[C@]4([H])[C@](O)(C)[C@H](O)CCC(O)(C)C)=O)([H])[C@]3(C)C1
Molecular Formula
C27H44O7
Molecular Weight
480.63
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9.|[2]Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84.|[3]Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49 (4) :1633-1645.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 3

Alternative Products

CatalogName
BUP00101-01Crustecdysone

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