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DCK1α-2

CAT: 0804-HY-169347-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169347-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DCK1α-2 is an orally active CK1α molecular glue degrader that targets p53 pathway-related targets. dCK1α-2 exhibits anti-tumor efficacy in mouse models and can increase the expression of p53-related genes.[1].
CAS Number
3085297-83-9
Product Name Alternative
LC-05-004
UNSPSC
12352005
Target
Casein Kinase; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dck1α-2.html
Smiles
O=C1N([C@@H]2C(NC(CC2)=O)=O)CC3=C1C=CC(C4=NC5=C(Cl)C(CN6CCOCC6)=NN5C=C4)=C3
Molecular Formula
C24H23ClN6O4
Molecular Weight
494.93
References & Citations
[1]Huang L, et al. Development of Oral, Potent, and Selective CK1α Degraders for AML Therapy. JACS Au. 2024 Nov 8;4 (11) :4423-4434.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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