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Neoandrographolide

CAT: 0804-HY-N0721-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0721-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates eNOS, exhibiting anti-inflammatory and hypolipidemic activity[1][2][3][4][5].
CAS Number
27215-14-1
Product Name Alternative
Neoandrographiside
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; CaMK; ERK; GSK-3; JNK; NF-κB; NO Synthase; p38 MAPK; PI3K; PPAR; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Neoandrographolide.html
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]([C@@H]1CCC2=CCOC2=O)(CCC3)[C@@](CCC1=C)([H])[C@]3(C)CO[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO
Molecular Formula
C26H40O8
Molecular Weight
480.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Tao Yang, et al. Hypolipidemic Effects of Andrographolide and Neoandrographolide in Mice and Rats. Phytotherapy Research Volume 27, Issue 4, pages 618–623, April 2013|[2]Tang K, et al., Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis. Front Pharmacol. 2025 Feb 11;16:1466057.|[3]Liu Y, et al., Amelioratory effect of neoandrographolide on myocardial ischemic-reperfusion injury by its anti-inflammatory and anti-apoptotic activities. Environ Toxicol. 2021 Dec;36 (12) :2367-2379.|[4]Liu J, et al., In vivo and in vitro anti-inflammatory activities of neoandrographolide. Am J Chin Med. 2007;35 (2) :317-28.|[5]Yang T, et al., Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats. Phytother Res. 2013 Apr;27 (4) :618-23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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