M1069

CAT: 0804-HY-148088-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-148088-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity[1][2][3].

CAS Number

3027658-65-4

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m1069.html

Purity

98.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C2C(SC(NC(N3C[C@]4(CCCOC4)CC3)=O)=N2)=C(C5=CCOCC5)C=N1.O=C(O)/C=C/C(O)=O

Molecular Formula

C25H30N4O8S

Molecular Weight

546.59

References & Citations

[1]Rinat Zaynagetdinov, et al. Abstract 3499: M1069 as dual A2A/A2B adenosine receptor antagonist counteracts immune-suppressive mechanisms of adenosine and reduces tumor growth in vivo. Cancer Res (2022) 82 (12_Supplement) :3499. |[2]Lillian L Siu, et al. Abstract CT240: A first-in-human study of the dual A2A/A2B adenosine receptor antagonist M1069 in patients with advanced solid tumors. Cancer Res (2022) 82 (12_Supplement) :CT240. |[3]Tanzer Eva-Maria, et al. Preparation of thiazolopyridine derivatives as adenosine receptor antagonists: World Intellectual Property Organization, WO2020152132[P]. 2020-07-30.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR)

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M1069

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