Transketolase-IN-4

Transketolase-IN-4

• CAS Number: 419547-73-2
• UNSPSC Description: Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].
• Target Antigen: Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/transketolase-in-4.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C1C=C(CC2=CC=CC=C2)NC3=C(C4=CC=C(C=C4)Cl)C=NN13
• Molecular Weight: 335.79
• References & Citations: [1]Du MX, et al. Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen. 2004 Aug;9(5):427-33.|[2]Mao J, et al. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported