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Azathramycin

CAT: 0804-HY-17442-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17442-01Size:50 mg
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Description
Azathramycin (Desmethyl Azithromycin) is a macrolide antibiotic. Azathramycin is a derivative of the anti-ribosomal antibiotic Azithromycin. Azathramycin exerts its antibacterial activity by binding to ribosomes and inhibiting bacterial protein synthesis. Azathramycin can selectively target and kill human senescent fibroblasts and is expected to be used in anti-aging research. Azathramycin affects multiple ion channels such as SCN5A, hERG, KCNQ1 + KCNE1, L-type Ca++ and Kir2.1[1][2][3].
CAS Number
76801-85-9
Product Name Alternative
Azaerythromycin A; Desmethyl Azithromycin
UNSPSC
12352005
Hazard Statement
H317, H334
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Azathramycin.html
Purity
99.85
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
C[C@H]1[C@H](O)[C@](C)(OC)C[C@]([H])(O[C@@H]([C@H](C)[C@@H](O[C@@]2([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O2)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@@](O)(C)[C@@H](CC)O3)[C@@H](C)C3=O)O1
Molecular Formula
C37H70N2O12
Molecular Weight
734.96
Precautions
H317, H334
References & Citations
[1]Santa Maria JP Jr, et al. Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase. ACS Chem Biol. 2017 Sep 15; 12 (9) : 2448–2456.|[2]Ozsvari B, et al. Azithromycin and Roxithromycin define a new family of "senolytic" drugs that target senescent human fibroblasts. Aging (Albany NY) . 2018 Nov 14;10 (11) :3294-3307.|[3]Yang Z, et al. Azithromycin Causes a Novel Proarrhythmic Syndrome. Circ Arrhythm Electrophysiol. 2017 Apr;10 (4) :e003560.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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