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Reproxalap

CAT: 0804-HY-107150-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107150-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Reproxalap (ADX-102) is an active aldehyde sequestering agent. Reproxalap reduces the PKCα activity. Reproxalap blocks caspase 3/7 activation. Reproxalap protects cells from the cytotoxicity of C18:0-al. Reproxalap has anti-inflammatory and pain-relieving effects. Reproxalap is used in studies of dry eye, allergic conjunctivitis, and non-infectious anterior uveitis[1][2][3][4][5].
CAS Number
916056-79-6
Product Name Alternative
ADX-102; NS-2
UNSPSC
12352005
Hazard Statement
H303, H313, H315, H319, H333, H335
Target
Caspase; PKC
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/reproxalap.html
Purity
98.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=NC2=C(C=C(Cl)C=C2)C=C1N)(O)C
Molecular Formula
C12H13ClN2O
Molecular Weight
236.70
Precautions
H303, H313, H315, H319, H333, H335
References & Citations
[1]Susan Macdonald, et al. ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain.|[2]Reproxalap Phase 2b Dry Eye Disease Results.|[3]Susan G. Macdonald, Ph.D., et al. Novel Small Molecule Aldehyde Sequestering Agents Demonstrate Broad Therapeutic Potential for Ocular Inflammation.|[4]Ochoa CA, et al. Aldehyde Trapping by ADX-102 Is Protective against Cigarette Smoke and Alcohol Mediated Lung Cell Injury. Biomolecules. 2022 Mar 2;12 (3) :393.|[5]Rizzo WB, et al. Sjögren-Larsson syndrome: A biochemical rationale for using aldehyde-reactive therapeutic agents. Mol Genet Metab Rep. 2021 Dec 23;30:100839.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Caspase 3; Caspase 7; PKCα

Alternative Products

CatalogName
MBS5769916Reproxalap
A19978-100Reproxalap 100mg
A19978-5Reproxalap 5mg
A19978-50Reproxalap 50mg
A19978-25Reproxalap 25mg
A19978-10Reproxalap 10mg
A19978-10mM-DReproxalap 10mM * 1mL in DMSO

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