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ST271

CAT: 0804-HY-103097-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-103097-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.
CAS Number
106392-48-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ST271.html
Purity
98.00
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N)/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1
Molecular Formula
C16H20N2O2
Molecular Weight
272.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Martinson EA, et al. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand) . 1994 Jul;40 (5) :627-34.|[2]Blake RA, et al. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor.|[3]Uings IJ, et al. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 (Pt 3) :597-600.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

ST 271
CAS Number106392-48-7
PubChem CID6439072
IUPAC Name(E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enamide
Molecular FormulaC16H20N2O2
Molecular Weight272.34
XLogP3
Topological Polar Surface Area87.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity413
SMILES
CC(C)C1=CC(=CC(=C1O)C(C)C)/C=C(\C#N)/C(=O)N
InChI
InChI=1S/C16H20N2O2/c1-9(2)13-6-11(5-12(8-17)16(18)20)7-14(10(3)4)15(13)19/h5-7,9-10,19H,1-4H3,(H2,18,20)/b12-5+
InChIKey
HMLQHJRJKQDTKW-LFYBBSHMSA-N
Chemical Structure
2D Structure
2D structure of ST 271
CAS: 106392-48-7
CID: 6439072
Formula: C16H20N2O2
MW: 272.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight272.34
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass272.152477885
Monoisotopic Mass272.152477885
Topological Polar Surface Area87.1 Ų
Heavy Atom Count20
Formal Charge0
Complexity413
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19170891-01ST271
A18329-2ST271 2mg
A18329-50ST271 50mg
A18329-10ST271 10mg
A18329-5ST271 5mg
A18329-100ST271 100mg
A18329-25ST271 25mg
A18329-10mM-DST271 10mM * 1mL in DMSO

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