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BOC-FlFlF

CAT: 0804-HY-P2355-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2355-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation[1][2].
CAS Number
66556-73-8
Product Name Alternative
BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe
UNSPSC
12352209
Target
Formyl Peptide Receptor (FPR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/boc-phe-leu-phe-leu-phe.html
Purity
98.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H](CC1=CC=CC=C1)NC([C@@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@@H](CC(C)C)NC([C@H](CC3=CC=CC=C3)NC(OC(C)(C)C)=O)=O)=O)=O)=O
Molecular Formula
C44H59N5O8
Molecular Weight
785.97
References & Citations
[1]Hayashi R, et al. Development of potent antagonists for formyl peptide receptor 1 based on Boc-Phe-D-Leu-Phe-D-Leu-Phe-OH. Bioorg Med Chem. 2014 Aug 1;22 (15) :3824-8. |[2]Stenfeldt AL, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30 (6) :224-9.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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