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Oveporexton

CAT: 0804-HY-159835-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-159835-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oveporexton (TAK-861) is an orally active and selective orexin receptor 2 (OX2R) agonist with an EC50 of 2.5 nM. Oveporexton exhibits 3000-fold selectivity for OX2R over OX1R. Oveporexton can be used for the study of hypersomnia disorders including narcolepsy[1][2].
CAS Number
2460722-04-5
Product Name Alternative
TAK-861
UNSPSC
12352101
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/oveporexton.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)(O)C(N(CC(F)([C@@H]1NS(CC)(=O)=O)F)[C@H]1CC2=C(C(C3=CC(F)=CC(F)=C3)=CC=C2)F)=O
Molecular Formula
C23H25F5N2O4S
Molecular Weight
520.51
References & Citations
[1]International Nonproprietary Names for Pharmaceutical Substances (INN) . WHO Drug Information, Vol. 38, No. 2, 2024.|[2]Mitsukawa K, et al. TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models. Sci Rep. 2024 Sep 6;14 (1) :20838.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX1 Receptor; OX2 Receptor

Alternative Products

CatalogName
GTR19239950-01Oveporexton
E4740-1mgOveporexton (TAK-861)

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