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IGF1Rtide

CAT: 0804-HY-P10044-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10044-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IGF1Rtide can be used as a RET kinase substrate for RET kinase assays[1].
CAS Number
172615-51-9
UNSPSC
12352209
Target
RET
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/igf1rtide.html
Purity
99.53
Solubility
H2O : 2.5 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N1[C@@H](CCC1)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CC=CC=C3)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Molecular Formula
C73H114N18O22
Molecular Weight
1595.79
References & Citations
[1]Nakaoku T, et al. A secondary RET mutation in the activation loop conferring resistance to vandetanib. Nat Commun. 2018 Feb 12;9 (1) :625.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Lys-lys-lys-ser-pro-gly-glu-tyr-val-asn-ile-glu-phe-gly-OH
CAS Number172615-51-9
PubChem CID57402973
IUPAC Name(4S)-4-[[2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S,3S)-1-[[(2S)-4-carboxy-1-[[(2S)-1-(carboxymethylamino)-1-oxo-3-phenylpropan-2-yl]amino]-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Molecular FormulaC73H114N18O22
Molecular Weight1595.8
XLogP-10.5
Topological Polar Surface Area669
Hydrogen Bond Donor Count22
Hydrogen Bond Acceptor Count26
Rotatable Bond Count54
Heavy Atom Count113
Formal Charge0
Complexity3170
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N
InChI
InChI=1S/C73H114N18O22/c1-5-41(4)61(72(112)84-49(27-29-58(98)99)67(107)85-50(63(103)80-38-59(100)101)34-42-16-7-6-8-17-42)90-69(109)52(36-55(78)94)87-71(111)60(40(2)3)89-68(108)51(35-43-22-24-44(93)25-23-43)86-66(106)48(26-28-57(96)97)81-56(95)37-79-70(110)54-21-15-33-91(54)73(113)53(39-92)88-65(105)47(20-11-14-32-76)83-64(104)46(19-10-13-31-75)82-62(102)45(77)18-9-12-30-74/h6-8,16-17,22-25,40-41,45-54,60-61,92-93H,5,9-15,18-21,26-39,74-77H2,1-4H3,(H2,78,94)(H,79,110)(H,80,103)(H,81,95)(H,82,102)(H,83,104)(H,84,112)(H,85,107)(H,86,106)(H,87,111)(H,88,105)(H,89,108)(H,90,109)(H,96,97)(H,98,99)(H,100,101)/t41-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,60-,61-/m0/s1
InChIKey
KVGQVWWLDJKNMP-YCOAWBJSSA-N
Chemical Structure
2D Structure
2D structure of H-Lys-lys-lys-ser-pro-gly-glu-tyr-val-asn-ile-glu-phe-gly-OH
CAS: 172615-51-9
CID: 57402973
Formula: C73H114N18O22
MW: 1595.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1595.8
XLogP3-10.5
Hydrogen Bond Donor Count22
Hydrogen Bond Acceptor Count26
Rotatable Bond Count54
Exact Mass1594.83550734
Monoisotopic Mass1594.83550734
Topological Polar Surface Area669 Ų
Heavy Atom Count113
Formal Charge0
Complexity3170
Isotope Atom Count0
Defined Atom Stereocenter Count13
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS516462-01IGF1Rtide

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