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Mofarotene

CAT: 0804-HY-127149-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-127149-01Size:1 mg
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Description
Mofarotene (Ro 40-8757), an arotinoid, is anticancer compound. Mofarotene induces apoptosis, associated with mitochondrial membrane depolarization, activation of caspase-3 and -9, and enhanced production of reactive oxygen species. Mofarotene inhibits hematopoiesis in vitro by inhibiting maturation from primitive progenitor cells[1][2][3].
CAS Number
125533-88-2
Product Name Alternative
Ro 40-8757
UNSPSC
12352005
Target
Apoptosis; Caspase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mofarotene.html
Solubility
10 mM in DMSO
Smiles
CC1(C2=CC(/C(C)=C/C3=CC=C(C=C3)OCCN4CCOCC4)=CC=C2C(C)(CC1)C)C
Molecular Formula
C29H39NO2
Molecular Weight
433.63
References & Citations
[1]Valles B, et al. Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Drug Metab Dispos. 1995 Oct;23 (10) :1051-7.|[2]Eliason JF, et al. Mofarotene (Ro 40-8757) inhibits hematopoiesis in vitro by preventing maturation from primitive progenitor cells. Blood. 1995 Dec 15;86 (12) :4516-26.|[3]Cariati R, et al. Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells. Oncogene. 2003 Feb 13;22 (6) :906-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Caspase 3; Caspase 9

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CatalogName
GTR19213668-01Mofarotene

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