Acarbose (Standard)

• Description :

  Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM) . Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin[1][2][3].

• Product Name Alternative :

  BAY g 5421 (Standard)

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Glycosidase; Reference Standards

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/acarbose-standard.html

• Purity :

  99.93

• Smiles :

  OC[C@H]([C@]1(O[C@@H]2[C@H](O)[C@@H](O)[C@@H]([C@H](O2)C)N[C@]3(C=C(CO)[C@H]([C@@H]([C@H]3O)O)O)[H])[H])O[C@@H]([C@@H]([C@H]1O)O)O[C@@]([H])([C@@H]([C@H](C=O)O)O)[C@@H](CO)O

• Molecular Formula :

  C25H43NO18

• Molecular Weight :

  645.60

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhang Q, et al. Acarbose Reduces Blood Glucose by Activating miR-10a-5p and miR-664 in Diabetic Rats. PLoS One. 2013 Nov 18;8 (11) :e79697.|[2]Chan KC, et al. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:3864|[3]Hanefeld M, et al. Acarbose: oral anti-diabetes drug with additional cardiovascular benefits [published correction appears in Expert Rev Cardiovasc Ther. 2009 Mar;7 (3) :330]. Expert Rev Cardiovasc Ther. 2008;6 (2) :153-163.|[4]Yee HS, et al. A review of the safety and efficacy of acarbose in diabetes mellitus. Pharmacotherapy. 1996;16 (5) :792-805.|[5]Oki T, et al. Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol Pharm Bull. 2000;23 (9) :1084-1087.|[6]Zhang Q, et al. Acarbose Reduces Blood Glucose by Activating miR-10a-5p and miR-664 in Diabetic Rats. PLoS One. 2013 Nov 18;8 (11) :e79697.|[7]Chan KC, et al. Pleiotropic effects of acarbose on atherosclerosis development in rabbits are mediated via upregulating AMPK signals. Sci Rep. 2016 Dec 7;6:3864|[8]Hanefeld M, et al. Acarbose: oral anti-diabetes drug with additional cardiovascular benefits [published correction appears in Expert Rev Cardiovasc Ther. 2009 Mar;7 (3) :330]. Expert Rev Cardiovasc Ther. 2008;6 (2) :153-163.|[9]Yee HS, et al. A review of the safety and efficacy of acarbose in diabetes mellitus. Pharmacotherapy. 1996;16 (5) :792-805.|[10]Oki T, et al. Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol Pharm Bull. 2000;23 (9) :1084-1087.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C, sealed storage, away from light and moisture

• Scientific Category :

  Reference Standards

• CAS Number :

  [56180-94-0]