Products for Research Use Only
RegisterLogin

Monascuspiloin

CAT: 0804-HY-N12124-01Size: 500 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N12124-01Size:500 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC50 of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC50 of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice[1][2].
CAS Number
1011244-19-1
Product Name Alternative
Monascinol
UNSPSC
12352005
Target
Akt; AMPK; Androgen Receptor; Apoptosis; Autophagy; mTOR
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/monascuspiloin.html
Purity
95
Smiles
C[C@]12[C@@](CC3=C(COC(/C=C/C)=C3)C2=O)([H])[C@H](C(O1)=O)[C@@H](O)CCCCC
Molecular Formula
C21H28O5
Molecular Weight
360.44
References & Citations
[1]Chen RJ, et al., Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathways. J Agric Food Chem. 2012 Jul 25;60 (29) :7185-93. |[2]Chiu HW, et al., Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy. PLoS One. 2012;7 (7) :e40462.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19223423Monascuspiloin

Popular Products