UMK57

CAT: 0804-HY-122236-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-122236-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis[1].

CAS Number

342595-74-8

UNSPSC

12352005

Target

Mitosis; Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/umk57.html

Purity

99.51

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 6.67 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1)C2=CSC3=NC=NC(N4CCCC4)=C32

Molecular Formula

C17H17N3S

Molecular Weight

295.40

References & Citations

[1]Bernardo Orr, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17 (7) :1755-1763.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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