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Lapiteronel

CAT: 0804-HY-19833-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-19833-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lapiteronel (CFG920) is an orally active, nonsteroidal, reversible dual CYP17 and CYP11B2 inhibitor. Lapiteronel has the potential for metastatic castration-resistant prostate cancer research[1][2].
CAS Number
1260006-20-9
Product Name Alternative
CFG920
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cfg920.html
Concentration
10mM
Purity
98.51
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C2=C(C)C=CN=C2)CCN1C3=CC(Cl)=NC=C3
Molecular Formula
C14H13ClN4O
Molecular Weight
288.73
References & Citations
[1]Chris Lu, et al. Method of treating cancer. WO2021026454A1.|[2]https://patents.google.com/patent/WO2021026454A1/en?oq=WO2021026454
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CYP11; CYP17

Chemical Information

Cfg-920

CFG-920 is under investigation in clinical trial NCT04060394 (Dose-escalation and Efficacy Study of Lae001/prednisone Plus Afuresertib Patients With M-crpc).

CAS Number1260006-20-9
PubChem CID49871869
IUPAC Name1-(2-chloro-4-pyridinyl)-3-(4-methyl-3-pyridinyl)imidazolidin-2-one
Molecular FormulaC14H13ClN4O
Molecular Weight288.73
XLogP1.8
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity367
SMILES
CC1=C(C=NC=C1)N2CCN(C2=O)C3=CC(=NC=C3)Cl
InChI
InChI=1S/C14H13ClN4O/c1-10-2-4-16-9-12(10)19-7-6-18(14(19)20)11-3-5-17-13(15)8-11/h2-5,8-9H,6-7H2,1H3
InChIKey
ZVIFCOOHWGNPHJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cfg-920
CAS: 1260006-20-9
CID: 49871869
Formula: C14H13ClN4O
MW: 288.73
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight288.73
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass288.0777887
Monoisotopic Mass288.0777887
Topological Polar Surface Area49.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity367
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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