Destruxin A

CAT: 0804-HY-N6689Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N6689Size:1 mg
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Description
Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections[1][2][3].
CAS Number
[6686-70-0]
UNSPSC
12352209
Hazard Statement
H302+H312+H332, H315, H319, H335
Target
Bacterial; Insecticide
Type
Natural Products
Related Pathways
Anti-infection; Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/destruxin-a.html
Purity
97.92
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
O=C1[C@]2(N(C([C@@]([H])(CC=C)OC(CCNC([C@@H](N(C([C@@]([H])(N(C([C@@]([H])(N1)[C@H](CC)C)=O)C)C(C)C)=O)C)C)=O)=O)=O)CCC2)[H]
Molecular Formula
C29H47N5O7
Molecular Weight
577.71
Precautions
H302+H312+H332, H315, H319, H335
References & Citations
[1]Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9 (5) :e96170.|[2]Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282 (12) :8969-77.|[3]Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74 (3) :267-71.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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