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Angelicin

CAT: 0804-HY-N0763-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0763-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM) . Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.
CAS Number
523-50-2
Product Name Alternative
Isopsoralen
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Caspase; JNK; NF-κB; p38 MAPK; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; MAPK/ERK Pathway; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Angelicin.html
Purity
99.98
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC=C(OC=C3)C3=C2O1
Molecular Formula
C11H6O3
Molecular Weight
186.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Rahman MA, et al. Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SY5Y neuroblastoma cells. Mol Cell Biochem. 2012 Oct;369 (1-2) :95-104.|[2]Cho HJ, et al. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Res. 2013 Oct;100 (1) :75-83.|[3]Liu F, et al. Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. J Surg Res. 2013 Nov;185 (1) :300-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 9

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