3,5,7,3′,4′-Pentamethoxyflavone
CAT:
804-HY-N7690-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
3,5,7,3′,4′-Pentamethoxyflavone
- CAS Number: 1247-97-8
- UNSPSC Description: 3,5,7,3’,4’-Pentamethoxyflavone is a Ca2+ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases[1][2][4].
- Target Antigen: Calcium Channel
- Type: Natural Products
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Metabolic Disease; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/3-5-7-3-4-pentamethoxyflavone.html
- Purity: 99.15
- Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C1C(OC)=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(OC)=CC(OC)=C13
- Molecular Weight: 372.37
- References & Citations: [1]Jakhar R, et al. 3,5,7,3',4'-pentamethoxyflavone, a quercetin derivative protects DNA from oxidative challenges: potential mechanism of action. J Photochem Photobiol B. 2014 Feb 5;131:96-103. |[2]Jansakul C, et al. Relaxant mechanisms of 3, 5, 7, 3', 4'-pentamethoxyflavone on isolated human cavernosum. Eur J Pharmacol. 2012 Sep 15;691(1-3):235-44. |[3]Mayangsari Y, et al. 3,5,7,3',4'-Pentamethoxyflavone Enhances the Barrier Function through Transcriptional Regulation of the Tight Junction in Human Intestinal Caco-2 Cells. J Agric Food Chem. 2021 Sep 8;69(35):10174-10183.|[4]Yorsin S, et al. Increased vascular eNOS and cystathionine-γ-lyase protein after 6 weeks oral administration of 3, 5, 7, 3', 4'-pentamethoxyflavone to middle-aged male rats. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1183-1194.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported