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Bavachinin

CAT: 0804-HY-N0234-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0234-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC50 value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity.[1][2][3][4][5].
CAS Number
19879-30-2
Product Name Alternative
7-O-Methylbavachin; Bavachinin A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β; HIF/HIF Prolyl-Hydroxylase; PPAR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Bavachinin.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(OC)=C(C/C=C(C)\C)C=C13
Molecular Formula
C21H22O4
Molecular Weight
338.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen X, et al. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. FEBS Lett. 2013 Sep 17;587 (18) :2930-5.|[2]Nepal M, et al. Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α. Eur J Pharmacol. 2012 Sep 15;691 (1-3) :28-37.|[3]Chen X, et al. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs. Cell Mol Immunol. 2013 Nov;10 (6) :497-505.|[4]Lu-Na Ge, et al. Bavachinin exhibits antitumor activity against non small cell lung cancer by targeting PPARγ. Mol Med Rep. 2019 Sep;20 (3) :2805-2811.|[5]Li Feng, et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice. Diabetologia. 2016 Jun;59 (6) :1276-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIF; PPARα; PPARβ/δ; PPARγ

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