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Orellanine

CAT: 0804-HY-W661499-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W661499-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC) [1][2].
CAS Number
37338-80-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/orellanine.html
Purity
98.0
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[O-][N+]1=CC=C(O)C(O)=C1C2=C(O)C(O)=CC=[N+]2[O-]
Molecular Formula
C10H8N2O6
Molecular Weight
252.18
Precautions
H315, H319, H335
References & Citations
[1]Lyons MJ, et al. Orellanine: From Fungal Origin to a Potential Future Cancer Treatment. J Nat Prod. 2023 Jun 23;86 (6) :1620-1631.|[2]Buvall L, et al. Orellanine specifically targets renal clear cell carcinoma. Oncotarget. 2017 Jul 25;8 (53) :91085-91098.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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